Abstract: The window chamber models, including the mammary window chamber model, the spine window chamber model and the craniocerebral window chamber model, are widely used in iconography, such as fluorescence imaging, ultrasound imaging, magnetic resonance imaging and PET imaging. The development of these imaging methods is of great importance to the study of the vascularity, metabolism, and drug therapy of the tissues in the windows, which is helpful to deepen understanding the progress of disease and the research on new treatment methods.