Abstract: A multi-cavity micro-perforated pipe muffler structure is proposed to solve the wide-band air intake noise problem for a vehicle air intake system at high speeds. Based on the transfer matrix method, a transmission loss calculation model for a multi-cavity micro-perforated tube muffler under flow condition is established. In order to study the spectral characteristics of the air intake noise of vehicle, a multi-group genetic algorithm is used to optimize the structural parameters of the multi-cavity micro-perforated tube muffler, and the muffling effect of the optimized muffler design is verified by the tests of impedance tube bench and actual vehicle. The results show that the optimized multi-cavity micro-perforated tube muffler can effectively widen the noise reduction band, and the prediction result of the transmission loss of the muffler is consistent with the test result, which verifies the accuracy of the proposed transmission loss calculation model and the effectiveness of the optimization algorithm. After the micro-perforated pipe muffler is used in the air intake system of the vehicle, the intake noise is significantly reduced in the mid-high frequency band of 600-1 800 Hz and the low frequency band of 200- 400 Hz, so the actual wideband muffling performance of the proposed multi-cavity micro-perforated pipe muffler is confirmed.