Abstract: This paper describes a way of using adaptive noise cancellation to eliminate periodic power pulse interference and others. The method takes periodic sinc(x)=sinc(πx)πx pulse signal, which simulates periodic power pulse interfering signal, with white noise as the reference input. The LMS algorithm and NLMS algorithm are used for the simulation of eliminating noise. In the three conditions of no gain, gain saturation and gain oversaturation, the outputs of MATLAB simulations for the input SNR of 3dB show that after using LMS algorithm and NLMS algorithm filtering, multiple echoes can be distinguished clearly.