Abstract: Based on the Keller-Miksis oscillation equation of a single bubble, a calculation model of double-bubble coupled oscillation model is established by considering the time delay. The model divides the period of bubble oscillation into several parts. An initial disturbance causes the radius of the first bubble changing in a very short time to generate oscillation and radiate sound pressure. The radiated sound pressure acts on the second bubble after a certain time of propagation. The second bubble also oscillates in a short time and feeds back to the first bubble, and then this process would be repeated over and over again. Based on this model, the effects of bubble oscillation amplitude, radius and spacing on coupled oscillation are studied by numerical simulation. The results show that the stronger the initial disturbance and the closer the radius of the two bubbles, the more obvious the coupling effect; the bubble with larger initial radius and equilibrium radius has a significant influence on the coupled oscillation, and the oscillation shifts to the lower frequency; the larger the bubble spacing the weaker the coupling effect; at a certain distance, the damping of the coupling effect between bubbles will decrease or increase abnormally.