Abstract: The sound absorption performance of lightweight and high temperature resistant micro-perforated panel absorber (MPPA) is mainly restricted by four parameters: cavity depth, aperture, panel thickness and perforation rate. The change of the sound absorption performance of micro-perforated panel absorber is observed by decreasing and increasing these parameters in equal proportion. The concept of change rate of sound absorption coefficient is introduced, which is taken as the measuring standard to judge the influence of changing these parameters on the sound absorption performance of the micro-perforated panel structure. Generally, the order of the four parameters with the sensitivities affecting sound absorption performance from high to low is as follows: cavity depth, aperture, perforation rate, and panel thickness. The research results can provide some guidance for engineers to design the size of the micro-perforated panel absorber when it is used for noise reduction.