Abstract: For the design of acoustic transmission window with high acoustic transmittance and low fluid exciting noise, a five-layer constrained damping sandwich structure is presented in this paper. Based on the transfer matrix method, the theoretical calculation formula of the acoustic transmittance of the five-layer constrained damping sandwich structure is derived, and the acoustic transmission performance test of this acoustic transmission window is carried out, which verifies the reliability of the theoretical formula. Based on the theoretical formula, the influences of different design parameters on the acoustic transmission performance of this acoustic transmission window are systematically studied. The results show that the acoustic transmittance of this acoustic transmission window changes periodically with the increase of frequency, and the overall trend is downward. The increase of the thickness of the constrained damping layer will change the periodic change law of the acoustic transmission performance. In the case where the middle layer is unchanged, the paving sequence of the acoustic transmission performance is symmetrical.