Abstract: In order to study the problem of air noise caused by mainline trains passing through a proposed high-speed railway comprehensive station area, the noise limits of the main structural areas and different functional spaces of the high-speed railway comprehensive station area were first determined. Then, based on the actual situation of the high-speed railway station area's buildings and spatial layout, considering factors such as sound source directionality, atmospheric absorption, building diffraction, reflection influence, and building appearance, a numerical model for predicting air noise in the high-speed railway station area was constructed using Cadna/A. The spatial distribution of noise in each area where mainline trains pass through the station area was analyzed. Finally, noise reduction measures such as installing sound barriers on both sides of the mainline track were proposed from the perspectives of noise source control and noise prevention in sensitive building areas. This study can provide engineering reference for the construction of comprehensive station areas similar to high-speed railways.