Abstract: With the increasing demands on underwater operations, the number, aperture, power, and frequency range of installed and used underwater acoustic devices have significantly increased and expanded. This has led to extremely complex acoustic compatibility issues on ships, affecting their normal operation. In view of these challenges, a systematic acoustic compatibility design methodology is proposed to guide ships in conducting acoustic compatibility design in a phased and systematic manner. This approach involves identifying and mitigating risks at each stage, addressing issues during the design phase to ensure the full realization of system performance. Furthermore, for the first time, lake trials were conducted on two underwater acoustic devices. Based on the analysis of interference causes during the lake trials, countermeasures were proposed and validated through simulations. These findings provide valuable references for future research and applications.