Abstract: High intensity focused ultrasound(HIFU)technique was originated in 1940s.For the lack of high precision of imaging and directing technique, it did not develop quickly at that time.It has many advantages than surgery,and has potential value of clinical applications.High intensity focused ultrasound technique has high precision in ablating tissues,and has much choice in transducers.It’s biological effects include:heating effects;cavitation;enhancing the effects of medicines and immunity function of body et al.Potential applications of HIFU technique have been explored in a number of clinical fields,including neurosurgery,urology,ophthalmology,oncology et al.