Abstract: The research on MMSE(minimum mean-square error estimation) NC(noise cancellation) algorithm,which has been fitted for single microphone NC in 3G terminal system,and the comparison between MMSE-LSA(Log-Spectra MMSE-STSA)NC algorithm and the original MMSE NC algorithm in performance and complexity of the algorithm have been made.And the aim is to find the better NC algorithm for 3G system.In the article the original MMSE algorithm is improved by MMSE-LSA NC algorithm in the two aspects of spectral gain computation and VAD algorithm: the improvement on spectral gain computation changes the original Bessel function algorithm to make the application easier in practice;the improvement on VAD algorithm makes the detection of the period of audio stop more precise to enhance the performance of NC.The subjective and objective evaluations prove that the MMSE-LSA(Log-Spectral Amplitude MMSE-STSA)NC algorithm is superior to the original MMSE NC algorithm.