Abstract: Ozone is a very strong oxidant with good ability in disinfection, oxidization and degradation of pollutants. However, ozone selectively oxidizes organics. As a new technology of organic pollutant degradation, the ultrasonic method, which effectively decomposes nondegradable pollutants, is becoming increasingly important in wastewater treatment. Degradation is enhanced by ozone with ultrasonic. The mechanism of degradation is investigated, and recent advances in wastewater treatment using this integrated method reviewed. Problems to be solved and the direction of future development in applications of the combined ultrasound and ozone techniques in wastewater treatment are pointed out.